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An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A GPX4 inhibitor; inhibits GPX4 activity by 71.7% at 1 µM; cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively); decreases intracellular GSH levels and induces lipid peroxidation and ferroptosis in 4T1 cells at 5 µM; reduces tumor growth in a 4T1 mouse xenograft model at 15 and 30 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More